Mesenchymal Stem Cell Therapy in Traumatic Spinal Cord Injury: A Systematic Review.

Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. Cell therapy, particularly with mesenchymal stem cells (MSCs), holds significant promise for TSCI treatment. This systematic review aims to analyze the efficacy, safety, and therapeutic potential of MSC-based cell therapies in TSCI. A comprehensive search of PUBMED and COCHRANE databases until February 2023 was conducted, combining terms such as "spinal cord injury," "stem cells," "stem cell therapy," "mesenchymal stem cells," and "traumatic spinal cord injury". Among the 53 studies initially identified, 22 (21 clinical trials and 1 case series) were included. Findings from these studies consistently demonstrate improvements in AIS (ASIA Impairment Scale) grades, sensory scores, and, to a lesser extent, motor scores. Meta-analyses further support these positive outcomes. MSC-based therapies have shown short- and medium-term safety, as indicated by the absence of significant adverse events within the studied timeframe. However, caution is required when drawing generalized recommendations due to the limited scientific evidence available. Further research is needed to elucidate the long-term safety and clinical implications of these advancements. Although significant progress has been made, particularly with MSC-based therapies, additional studies exploring other potential future therapies such as gene therapies, neurostimulation techniques, and tissue engineering approaches are essential for a comprehensive understanding of the evolving TSCI treatment landscape.

Prognostic value of early magnetic resonance imaging in the morbidity and mortality of traumatic spinal cord injury.

OBJECTIVE: To assess in individuals with traumatic spinal cord injury (TSCI) the relationship between mortality and need for ICU and early magnetic resonance imaging (MRI), analyzing spinal parenchymal alterations, disruption of vertebral ligaments (DVL) and spinal cord compression (SCC). DESIGN: Retrospective study. SETTING: Third-level hospital, Spinal Cord Injury Unit and ICU. PATIENTS: Individuals with acute TSCI between 2010 and 2019. INTERVENTION: Analysis of MRI performed in the first 72 h. VARIABLES OF INTEREST: Admission to ICU and mortality. RESULTS: 269 cases collected. The pattern that demonstrated higher mortality was cord hemorrhage (16.7%) for 12.5% ​​of single-level edema and 6.5% of multilevel edema (p = 0.125). The same happened with ICU admissions: 69.0% in hemorrhage, 60.2% in multilevel edema and 46.3% in short edema (p = 0.018). Analyzing CCM, mortality was 13.4% with 59.2% of ICU admissions, for 2.2% and 42.2% of individuals without cord compression (p = 0.020 and p = 0.003). The figures of death and ICU admission among cord injuries with DVL were 15.0% and 67.3%, for 6.2% and 44.4% of the individuals without DLV (p < 0.001 and p = 0.013). CONCLUSIONS: The presence of spinal cord hemorrhage, SCC and DVL was associated with a higher admission in ICU. A significant increase in mortality was observed in cases with SCC and DVL.

Evaluation of the prognostic value of extra-parenchymal changes in traumatic spinal cord injury, assessed by magnetic resonance imaging.

OBJECTIVES: To analyze the relationship between neurological progression following traumatic spinal cord injury and Spinal Cord Compression (SCC) and Spinal Ligamentous Injury (LI) by magnetic resonance imaging. DESIGN: Retrospective observational study. SETTING: Spinal Cord Injury Unit (A Coruña, Spain). PARTICIPANTS: Patients were admitted for traumatic spinal cord injury between January 2010 and December 2018 with a magnetic resonance imaging examination performed during the acute phase. INTERVENTION: Evaluation of SCC and LI by magnetic resonance imaging. OUTCOME MEASURES: Comparisons between neurological examination at admission and discharge were made, assessing ASIA Impairment Scale (AIS) grade and motor score. RESULTS: Data from 296 patients were collected. A relationship between SCC and LI and complete injuries were found (P < 0.001). Improvement of the AIS grade was observed in 31.6% of patients with SCC and 31.3% with LI versus 42.7% and 37.8% of subjects without these complications, respectively. Regarding motor score, patients with SCC had lower mean values at the beginning (46.9 ± 26.8 versus 61.1 ± 29.9 in the control group, P < 0.001), as well as less improvement when assessed by the percentage of change (35.1 ± 37.5% versus 49.4 ± 38.1% in the control group, P = 0.010). Similar results were obtained in cases with LI: mean motor score at admission was 45.9 ± 26.7 versus 54.9 ± 29.4 in the control group (P = 0.014) and the percentage of change was 28.5 ± 37.1% in comparison to 46.0 ± 37.5% (P = 0.001) in the controls. CONCLUSIONS: There is a relationship between SCC and LI and complete spinal cord injury. This patient population has lower possibilities of improving their AIS grade and motor score.

Neurological recovery after traumatic spinal cord injury: prognostic value of magnetic resonance.

STUDY DESIGN: Retrospective observational study. OBJECTIVES: Assess the relationship between Magnetic Resonance (MR) image patterns and neurological recovery in patients with Traumatic Spinal Cord Injury (TSCI). SETTING: Spinal cord injury unit in Spain. METHODS: Patients admitted for acute TSCI between January 2010 and December 2018 with a MR exam performed in the acute phase were selected. Five patterns were established: normal, single-level edema, multilevel edema, hemorrhage, and spinal cord transection. Comparisons between the ASIA Injury Severity (AIS) score and Motor Index (MI) at admission and at discharge were made. RESULTS: Collected 296 patients. Normal and cord transection patterns were excluded due to the low number of cases. Single-level edema pattern was primarily observed in cases with incomplete injuries, hemorrhage pattern in complete injuries, and multilevel edema pattern at similar percentages in complete and incomplete lesions. Improvement of the AIS score was found in 40.9% of single-level edema, 20.2% of multilevel edema, and 19.0% of hemorrhage (p = 0.042) patterns. By excluding the AIS grade D from the analyses, the figures increased to 70.3%, 52.2%, and 19.4% respectively (p < 0.001). This significant relationship was confirmed by multivariate analysis, although it was not as relevant as the examination according to ASIA-ISCoS performed at admission (p = 0.005 vs p < 0.001). Mean variation of the MI was also significantly different (p < 0.001) between the three groups: 22.6 ± 21.4 for single-level edema, 16.9 ± 21.1 for multilevel edema, and 4.5 ± 8.4 for hemorrhage. CONCLUSION: MR injury patterns observed at the acute phase are associated with the possibility of improvement of the AIS score and MI.

Organ dysfunction as determined by the SOFA score is associated with prognosis in patients with acute traumatic spinal cord injury above T6.

STUDY DESIGN: This is a retrospective, observational study. OBJECTIVES: To evaluate organ dysfunction in patients with an acute traumatic spinal cord injury (ATSCI) above T6 using the Sequential Organ Failure Assessment (SOFA) score to determine its association with mortality. SETTING: The study was performed at the intensive care unit (ICU) of a tertiary hospital in the northwest of Spain. METHODS: The study included 241 patients with an ATSCI above T6 who had been admitted to the ICU between 1998 and 2017. A descriptive analysis of all variables collected was performed to compare the survivors with the non-survivors. In addition, a logistic regression model was used in the multivariate analysis to identify variables that were independently associated with mortality. RESULTS: The results revealed significant differences between the survivors and non-survivors in terms of their age, Charlson Comorbidity Index, Glasgow Coma Scale score on admission, APACHE II score, SOFA score on day 0 and day 4, and delta SOFA 4-0 (ΔSOFA 4-0). The results of this multivariate analysis identified the following variables as independent predictors of intra-ICU mortality: age (OR = 1.05; 95% CI: 1. 01-1.08), SOFA score on day 0 (OR = 1.42; 95% CI: 1.13-1.78), ΔSOFA 4-0 (OR = 1.53; 95% CI: 1.25-1.87), and fluid balance on day 4 (OR = 1.16; 95% CI: 1.00-1.35). CONCLUSIONS: The SOFA score is useful for evaluating organ dysfunction in patients with an ATSCI above T6. After adjusting the analysis for conventional variables, organ dysfunction on admission, changes in organ function between day 4 and day 0 (ΔSOFA 4-0), and fluid balance on day 4 were seen to be independently associated with mortality in our study.

Características clínicas y pronóstico de la lesión medular traumática en pacientes mayores de 75 años / Clinical characteristics and prognosis of spinal cord injury in individuals over 75 years old

Objetivos Analizar la incidencia y las características de la lesión medular (LM) traumática en la población geriátrica de Galicia (España), el manejo hospitalario y el pronóstico vital y funcional. Material y métodos Estudio comparativo retrospectivo. Se incluyen los pacientes ingresados por LM traumática aguda entre enero de 2010 y diciembre de 2016. Se establecen 2 grupos: mayores y menores de 75 años, actuando los últimos como grupo control. Resultados Recogidos 379 pacientes (27,2% ≥75 años). La etiología más frecuente en el grupo ≥75 años fueron las caídas: 80,6%. El 65,7% presentaban lesiones medulares incompletas con un índice motor (IM) medio de 44,9/100. Al alta el 90,8% eran dependientes, precisando silla de ruedas el 53,8%. La mortalidad hospitalaria fue del 34,9%. En comparación con el grupo control, los pacientes mayores sufrieron más lesiones cervicales (74,8 vs. 51,2%; p<0,001), mayor retraso diagnóstico (31,1 vs. 9,2%; p<0,001) y mortalidad hospitalaria (34,9 vs. 3,2%; p<0,001). Se realizaron menos intervenciones quirúrgicas y con mayor demora. Los porcentajes de ingreso en la UCI, ventilación mecánica y realización de traqueostomía fueron similares. No se encontraron diferencias significativas en cuanto a evolución neurológica según la escala American Spinal Injury Association (ASIA) (p=0,46) o el IM (p=0,48). Conclusiones 1) La frecuencia de LM traumática en ancianos en Galicia es elevada; 2) La evolución neurológica medida por el ASIA es similar a pacientes más jóvenes, si bien el nivel de dependencia al alta es mayor; 3) El nivel de cuidados hospitalarios es similar en ambos grupos salvo por la indicación quirúrgica, y 4) La mortalidad hospitalaria es alta (AU)

Objective To analyze the incidence and characteristics of traumatic spinal cord injury (SCI) in geriatric population of Galicia (Spain), hospital management and functional prognosis. Methods Comparative retrospective study. Patients admitted with acute traumatic SCI during the time period between January 2010 and December 2016 were included. Two groups established: The elderly over and under 75 years of age, with the latter acting as a control group. Results Three hundred seventy-nine patients were studied (27.2% ≥75 years). The main etiology in the >75 years group were falls: 80.6%. There were 65.7% who presented incomplete spinal cord injuries with mean motor index (MI) of 44.9/100. Upon discharge, 90.8% were dependent. Hospital mortality was 34.9%. Those >75 years suffered from more cervical injuries (74.8 vs. 51.2%; p<0.001), longer delay in diagnosis (31.1 vs. 9.2%; p<0.001) and higher hospital mortality (34.9 vs. 3.2%; p<0.001). Fewer surgical interventions were performed, with a longer delay. Percentages for admission into ICU, mechanical ventilation and performing a tracheostomy proved to be similar. There were no significant differences found in the evolution according to the ASIA scale or the MI. Conclusions 1) The frequency of traumatic SCI in the elderly in Galicia is high; 2) Neurological evolution is similar to younger patients but the level of dependence is higher; 3) The level of care provided is similar in both groups, except for the surgical indication, and 4) Hospital mortality is high (AU)

Clinical characteristics and prognosis of spinal cord injury in individuals over 75 years old.

OBJECTIVE: To analyze the incidence and characteristics of traumatic spinal cord injury (SCI) in geriatric population of Galicia (Spain), hospital management and functional prognosis METHODS: Comparative retrospective study. Patients admitted with acute traumatic SCI during the time period between January 2010 and December 2016 were included. Two groups established: The elderly over and under 75 years of age, with the latter acting as a control group. RESULTS: 379 patients were studied (27.2% ≥75 years). The main etiology in the >75 years group were falls: 80.6%. There were 65.7% who presented incomplete spinal cord injuries with mean motor index (MI) of 44.9/100. Upon discharge, 90.8% were dependent. Hospital mortality was 34.9%. Those >75 years suffered from more cervical injuries (74.8 vs. 51.2%, p < 0.001), longer delay in diagnosis (31.1% vs. 9.2%, p < 0.001) and higher hospital mortality (34.9% vs. 3.2%, p < 0.001). Fewer surgical interventions were performed, with a longer delay. Percentages for admission into ICU, mechanical ventilation and performing a tracheostomy proved to be similar. There were no significant differences found in the evolution according to the ASIA scale or the MI. CONCLUSIONS: 1) The frequency of traumatic SCI in the elderly in Galicia is high. 2) Neurological evolution is similar to younger patients but the level of dependence is higher. 3) The level of care provided is similar in both groups, except for the surgical indication. 4) Hospital mortality is high.

Lesión medular como complicación de la vertebroplastia y la cifoplastia / Spinal cord injury as a complication of vertebroplasty and kyphoplasty

La vertebroplastia y la cifoplastia son técnicas percutáneas mínimamente invasivas que se hallan indicadas en el tratamiento del dolor asociado con fracturas vertebrales osteoporóticas y tumorales. Aunque han demostrado ser técnicas seguras, pueden dar lugar a complicaciones derivadas de la llamada 'fuga de cemento'. Presentamos el caso clínico de dos mujeres con 37 y 62 años, quienes presentaron fracturas toracolumbares múltiples, la primera de etiología traumática y la segunda osteoporótica, con afectación de muro posterior. Tras implementarse dichas técnicas las pacientes presentaron lesión medular incompleta por escape de cemento al canal medular; en el segundo caso se produjo también embolismo pulmonar por cemento. A fin de solucionar dichas complicaciones, se realizaron sendas laminectomías con extracción del material y las pacientes ingresaron a tratamiento rehabilitador; en la paciente con embolismo se inició procedimiento de anticoagulación. Al alta, ambas presentaban mejoría exploratoria y realizaban marcha con ortesis. Se concluye que la vertebroplastia y la cifoplastia son técnicas relativamente seguras aunque no exentas de complicaciones, pues la fuga de cemento a los plexos venosos constituye una complicación conocida y reportada. Es importante una apropiada selección de pacientes, comprobando la integridad del muro posterior; así mismo, los pacientes deben ser evaluados cuidadosamente desde el punto de vista respiratorio.

Vertebroplasty and kyphoplasty are minimally invasive percutaneous techniques indicated for the treatment of pain associated with osteoporotic and tumor vertebral fractures. Although they have proven to be safe techniques, they can give rise to complications derived from the so-called 'cement leakage'. We present the clinical case of two women aged 37 and 62 years, who presented multiple thoracolumbar fractures, the first of traumatic etiology and the second osteoporotic, with posterior wall involvement. After implementing these techniques, the patients presented incomplete medullary lesion due to cement leakage into the medullary canal; in the second case there was also pulmonary embolism due to cement. In order to solve these complications, two laminectomies were performed with removal of the material and the patients were admitted for rehabilitation treatment; in the patient with embolism, anticoagulation procedure was started. At discharge, both patients showed exploratory improvement and were walking with orthosis. We conclude that vertebroplasty and kyphoplasty are relatively safe techniques, although they are not free of complications, since cement leakage to the venous plexus is a known and reported complication. Appropriate patient selection is important, checking the integrity of the posterior wall; likewise, patients should be carefully evaluated from the respiratory point of view.

Clinical characteristics and prognosis of spinal cord injury in individuals over 75 years old. / Características clínicas y pronóstico de la lesión medular traumática en pacientes mayores de 75 años.

OBJECTIVE: To analyze the incidence and characteristics of traumatic spinal cord injury (SCI) in geriatric population of Galicia (Spain), hospital management and functional prognosis. METHODS: Comparative retrospective study. Patients admitted with acute traumatic SCI during the time period between January 2010 and December 2016 were included. Two groups established: The elderly over and under 75 years of age, with the latter acting as a control group. RESULTS: Three hundred seventy-nine patients were studied (27.2% ≥75 years). The main etiology in the >75 years group were falls: 80.6%. There were 65.7% who presented incomplete spinal cord injuries with mean motor index (MI) of 44.9/100. Upon discharge, 90.8% were dependent. Hospital mortality was 34.9%. Those >75 years suffered from more cervical injuries (74.8 vs. 51.2%; p<0.001), longer delay in diagnosis (31.1 vs. 9.2%; p<0.001) and higher hospital mortality (34.9 vs. 3.2%; p<0.001). Fewer surgical interventions were performed, with a longer delay. Percentages for admission into ICU, mechanical ventilation and performing a tracheostomy proved to be similar. There were no significant differences found in the evolution according to the ASIA scale or the MI. CONCLUSIONS: 1) The frequency of traumatic SCI in the elderly in Galicia is high; 2) Neurological evolution is similar to younger patients but the level of dependence is higher; 3) The level of care provided is similar in both groups, except for the surgical indication, and 4) Hospital mortality is high.

Product evaluation of Hollister's Onli™ ready-to-use hydrophilic intermittent catheter and adherence to a treatment plan using this catheter. / Evaluación del producto catéter intermitente hidrofílico listo para usar Onli™ de Hollister y adherencia a un plan de tratamiento usando este catéter.

OBJECTIVE: The primary objective of this product evaluation involved obtaining assessments from patients following the use of the Onli™ intermittent catheter(IC) 17cm and 40cm; and opinions from clinicians on its use for catheterization based on its design features.The inability to access the right catheter is often why patients discontinue intermittent self-catheterization(1). Design factors play an important role in the like lihood of using and remaining compliant to an IC device.The secondary objective of this product evaluation was to assess if the ease-of-learning and ease-of-use of Onli intermittent catheter, would support patient adherence to a catheterization treatment plan. METHODS: A multi-center, unblinded evaluation was executed in 10 different SCI Units across Spain. Rehabilitation physicians and nurses recruited patients with neurogenic bladder disorder and used IC's. The patient sused 30 catheters in according to their standard of care.A total of 100 subjects were enrolled into the study (78 male and 22 female). RESULTS: 90% of clinicians agreed that the "ease-oflearning"and "ease-of-use" of the Onli intermittent catheter has the potential to support patient adherence to a catheterization plan. 80% of patients found learning curve for catheter usage easy, and 69% found it easier than their current catheter. A total of 89% of patients reported insertion of the catheter as easy or very easy;with 91% reporting removal easy or very easy. CONCLUSION: Results of the current evaluation support increased adherence to a self-cath treatment plan.The IC was described as easy to teach and learn; with77% of patients indicating that if the IC was available they would be likely or very likely to use it. Other designat tributes of the IC were found to lend to the preference for the selection of the product.

OBJETIVO: El objetivo principal de la evaluaciónde este producto consistió en la obtención de evaluaciones de los pacientes tras el uso del catéter intermitente (CI) Onli™, de 17 cm y 40 cm, y de las opiniones de los profesionales sanitarios sobre su uso para el cateterismo en función de sus características de diseño. La imposibilidad de acceder al catéter correcto suele ser el motivo por el cual los pacientes suspenden el autocateterismo intermitente (1). Los factores de diseño juegan un rol importante en la probabilidad de usar un CI y seguir el tratamiento. El objetivo secundario de la evaluación de este producto consistió en evaluar si la facilidad de aprendizaje y de uso de este catéter intermitente Onli facilitaría la adherencia del paciente a un plan de tratamiento con sondaje vesical intermitente. MÉTODOS: Se realizó un estudio multicéntrico abierto en 10 Unidades de Lesión Medular (ULMs) de distintos lugares de España. Los médicos y la enfermería de Rehabilitación reclutaron pacientes de las ULMs con vejiga neurógena y que usaban CI o se les pautó CI. Los pacientes utilizaron 30 catéteres de acuerdo con su estándar de atención. En total, se incluyeron 100 sujetos en el estudio (78 hombres y 22 mujeres). RESULTADOS: Los resultados mostraron que el 90% de los profesionales sanitarios estuvieron de acuerdo con que la "facilidad de aprendizaje" y la "facilidad de uso" de la sonda Onli pueden potencialmente favorecer la adherencia del usuario a un plan de tratamiento con cateterismo intermitente, que un 80% de los pacientes consideró que aprender a usar el catéter era fácil y que a un 69% le resultó más fácil aprender a utilizar Onlique su sonda habitual. En total, el 89% de los pacientes consideró que la inserción del catéter fue fácil o muy fácil, y para un 91% resultó fácil o muy fácil la retirada. CONCLUSIÓN: Los resultados de esta evaluación respaldan las probabilidades de adherencia del pacientea un plan de tratamiento con cateterismos. Se determinó que el CI es fácil de enseñar y aprender, y un 77% de los pacientes indicaron que si el CI estuviera disponible probablemente o muy probablemente lo usarían. Se puede concluir que los factores de diseño juegan un papel importante en la selección del dispositivo, así como en su adherencia. Se descubrió que otros atributos del diseño del CI aportan a la preferencia en la selección del producto.

Evaluación del producto catéter intermitente hidrofílico listo para usar Onli(TM) de Hollister y adherencia a un plan de tratamiento usando este catéter / Product evaluation of Hollister's Onli(TM) ready-to-use hydrophilic intermittent catheter and adherence to a treatment plan using this catheter

OBJETIVO: El objetivo principal de la evaluaciónde este producto consistió en la obtención de evaluaciones de los pacientes tras el uso del catéter intermitente (CI) Onli(TM), de 17 cm y 40 cm, y de las opiniones de los profesionales sanitarios sobre su uso para el cateterismo en función de sus características de diseño. La imposibilidad de acceder al catéter correcto suele ser el motivo por el cual los pacientes suspenden el autocateterismo intermitente (1). Los factores de diseño juegan un rol importante en la probabilidad de usar un CI y seguir el tratamiento. El objetivo secundario de la evaluación de este producto consistió en evaluar si la facilidad de aprendizaje y de uso de este catéter intermitente Onli facilitaría la adherencia del paciente a un plan de tratamiento con sondaje vesical intermitente. MÉTODOS: Se realizó un estudio multicéntrico abierto en 10 Unidades de Lesión Medular (ULMs) de distintos lugares de España. Los médicos y la enfermería de Rehabilitación reclutaron pacientes de las ULMs con vejiga neurógena y que usaban CI o se les pautó CI. Los pacientes utilizaron 30 catéteres de acuerdo con su estándar de atención. En total, se incluyeron 100 sujetos en el estudio (78 hombres y 22 mujeres). RESULTADOS: Los resultados mostraron que el 90% de los profesionales sanitarios estuvieron de acuerdo con que la "facilidad de aprendizaje" y la "facilidad de uso" de la sonda Onli pueden potencialmente favorecer la adherencia del usuario a un plan de tratamiento con cateterismo intermitente, que un 80% de los pacientes consideró que aprender a usar el catéter era fácil y que a un 69% le resultó más fácil aprender a utilizar Onlique su sonda habitual. En total, el 89% de los pacientes consideró que la inserción del catéter fue fácil o muy fácil, y para un 91% resultó fácil o muy fácil la retirada. CONCLUSIÓN: Los resultados de esta evaluación respaldan las probabilidades de adherencia del pacientea un plan de tratamiento con cateterismos. Se determinó que el CI es fácil de enseñar y aprender, y un 77% de los pacientes indicaron que si el CI estuviera disponible probablemente o muy probablemente lo usarían. Se puede concluir que los factores de diseño juegan un papel importante en la selección del dispositivo, así como en su adherencia. Se descubrió que otros atributos del diseño del CI aportan a la preferencia en la selección del producto

OBJECTIVE: The primary objective of this product evaluation involved obtaining assessments from patients following the use of the Onli™ intermittent catheter(IC) 17cm and 40cm; and opinions from clinicians on its use for catheterization based on its design features.The inability to access the right catheter is often why patients discontinue intermittent self-catheterization(1). Design factors play an important role in the like lihood of using and remaining compliant to an IC device.The secondary objective of this product evaluation was to assess if the ease-of-learning and ease-of-use of Onli intermittent catheter, would support patient adherence to a catheterization treatment plan. METHODS: A multi-center, unblinded evaluation was executed in 10 different SCI Units across Spain. Rehabilitation physicians and nurses recruited patients with neurogenic bladder disorder and used IC's. The patient sused 30 catheters in according to their standard of care.A total of 100 subjects were enrolled into the study (78 male and 22 female). RESULTS: 90% of clinicians agreed that the "ease-oflearning"and "ease-of-use" of the Onli intermittent catheter has the potential to support patient adherence to a catheterization plan. 80% of patients found learning curve for catheter usage easy, and 69% found it easier than their current catheter. A total of 89% of patients reported insertion of the catheter as easy or very easy;with 91% reporting removal easy or very easy. CONCLUSION: Results of the current evaluation support increased adherence to a self-cath treatment plan.The IC was described as easy to teach and learn; with77% of patients indicating that if the IC was available they would be likely or very likely to use it. Other designat tributes of the IC were found to lend to the preference for the selection of the product

[Spanish consensus document for the diagnosis, treatment and management of neurogenic bladder.] / Documento de consenso español para el diagnóstico, el tratamiento y el manejo de la vejiga neurógena.

OBJECTIVES: The purpose of this document is to establish practical recommendations on neurogenic bladder (NB) management based on scientific evidence and medical and nursing perspective in Spinal Cord Injury (SCI) Units as a first multidisciplinary consensual approach in Spain. METHODS: This paper reports results from the first modified Delphi consensus building exercise on this procedure. A committee of recognised opinion-leaders in rehabilitation and urology with special interest in NB was constituted. A working group formed by rehabilitation doctors, urologists and nursing staff of SCI and Neurorehabilitation Units of a number of Spanish hospitals and specialised centres associated with the panel of NB experts have prepared this document. RESULTS: This review provided an overview of the main aspects described by the different clinical guidelines already available and highlighted the need to focus on recommendations in special priority situations in which there was no consensus. In view of the considerable impact this condition has on quality of life, patients should be offered help to better understand the disorder and they should be taught how to use the treatment techniques to obtain satisfactory results and promote their autonomy. CONCLUSIONS: This article presents a version of guidelines for patients with NB. The guidelines define the clinical profile of patients to provide the best evidence- based care and also an overview of the current drug and surgical treatments of NB.

OBJETIVO: El objetivo de este documento es establecer recomendaciones prácticas sobre el manejo de la vejiga neurógena (VN) en función de la evidencia científica y las perspectivas médicas y de enfermería en Unidades de Lesionados Medulares (ULM) como un primer enfoque de consenso multidisciplinar en España.MÉTODOS: En este artículo se presentan los resultados del primer ejercicio de consenso basado en metodología Delphi modificada sobre este procedimiento. Se constituyó un comité del que formaron parte reconocidos expertos en rehabilitación y urología, especializados en el manejo de VN. Este documento ha sido elaborado por un grupo de trabajo formado por médicos especialistas en rehabilitación, urólogos y personal de enfermería de ULM y unidades de Neurorrehabilitación de varios hospitales y centros especializados españoles asociados con el panel de expertos sobre VN. RESULTADOS: Esta revisión ofrece un resumen de los principales aspectos descritos en diversas guías clínicas ya disponibles y destaca la necesidad de centrarse en recomendaciones sobre situaciones especialmente prioritarias sobre las que actualmente no existe consenso. En vista del considerable impacto de esta enfermedad sobre la calidad de vida, los pacientes deben recibir ayuda para que comprendan mejor su enfermedad y también deben recibir formación sobre el uso de técnicas de tratamiento para conseguir resultados satisfactorios y fomentar su autonomía. CONCLUSIONES: En este artículo se presenta una versión de la guía para el manejo de pacientes con VN. Las guías definen el perfil clínico de los pacientes para ofrecer la mejor asistencia basada en la evidencia y también un resumen de los tratamientos farmacológicos y quirúrgicos actuales para la VN.

Documento de consenso español para el diagnóstico, el tratamiento y el manejo de la vejiga neurógena / Spanish consensus document for the diagnosis, treatment and management of neurogenic bladder

Objetivo: El objetivo de este documento es establecer recomendaciones prácticas sobre el manejo de la vejiga neurógena (VN) en función de la evidencia científica y las perspectivas médicas y de enfermería en Unidades de Lesionados Medulares (ULM) como un primer enfoque de consenso multidisciplinar en España. Métodos: En este artículo se presentan los resultados del primer ejercicio de consenso basado en metodología Delphi modificada sobre este procedimiento. Se constituyó un comité del que formaron parte reconocidos expertos en rehabilitación y urología, especializados en el manejo de VN. Este documento ha sido elaborado por un grupo de trabajo formado por médicos especialistas en rehabilitación, urólogos y personal de enfermería de ULM y unidades de Neurorrehabilitación de varios hospitales y centros especializados españoles asociados con el panel de expertos sobre VN Resultados: Esta revisión ofrece un resumen de los principales aspectos descritos en diversas guías clínicas ya disponibles y destaca la necesidad de centrarse en recomendaciones sobre situaciones especialmente prioritarias sobre las que actualmente no existe consenso. En vista del considerable impacto de esta enfermedad sobre la calidad de vida, los pacientes deben recibir ayuda para que comprendan mejor su enfermedad y también deben recibir formación sobre el uso de técnicas de tratamiento para conseguir resultados satisfactorios y fomentar su autonomía. Conclusiones: En este artículo se presenta una versión de la guía para el manejo de pacientes con VN. Las guías definen el perfil clínico de los pacientes para ofrecer la mejor asistencia basada en la evidencia y también un resumen de los tratamientos farmacológicos y quirúrgicos actuales para la VN

Objectives: The purpose of this document is to establish practical recommendations on neurogenic bladder (NB) management based on scientific evidence and medical and nursing perspective in Spinal Cord Injury (SCI) Units as a first multidisciplinary consensual approach in Spain. METHODS: This paper reports results from the first modified Delphi consensus building exercise on this procedure. A committee of recognised opinion-leaders in rehabilitation and urology with special interest in NB was constituted. A working group formed by rehabilitation doctors, urologists and nursing staff of SCI and Neurorehabilitation Units of a number of Spanish hospitals and specialised centres associated with the panel of NB experts have prepared this document. Results: This review provided an overview of the main aspects described by the different clinical guidelines already available and highlighted the need to focus on recommendations in special priority situations in which there was no consensus. In view of the considerable impact this condition has on quality of life, patients should be offered help to better understand the disorder and they should be taught how to use the treatment techniques to obtain satisfactory results and promote their autonomy. CONCLUSIONS: This article presents a version of guidelines for patients with NB. The guidelines define the clinical profile of patients to provide the best evidence based care and also an overview of the current drug and surgical treatments of NB

A validity study of the Spanish-World Health Organization Quality of Life short version instrument in persons with traumatic spinal cord injury.

STUDY DESIGN: This was a psychometric study. OBJECTIVES: To determine the validity of the Spanish version of the World Health Organization Quality of Life instrument (WHOQOL-BREF) for its use in persons with traumatic spinal cord injury and, as secondary objectives, to correlate the results with variables such as functional status, psychological well-being, and social support. SETTING: Spinal Cord Injury Unit, Complejo Hospitalario Universitario de A Coruña, Galicia (Spain). METHODS: Fifty-four people with spinal cord injury were enrolled in this study. Relevant variables were analyzed based on the scores reported by each participant in the Spanish versions of the WHOQOL-BREF questionnaire, the Spinal Cord Independence Measure, the Hospital Anxiety and Depression Scale (HADS), and the Duke-UNC Functional and Social Support Questionnaire. Both parametric and non-parametric tests were used to compare various variables. The instrument's internal consistency and test-retest reliability were also confirmed. RESULTS: The mean scores of each domain of the WHOQOL-BREF were lower, but nonsignificant, among people who need help to perform activities of daily living. The correlation between the scores obtained in the "Psychological" domain and the items of the HADS scale was significant. Significant differences were also observed when comparing the results of the "Social relationships" and "Environment" domains among people with low scores in the Duke questionnaire. Both an adequate consistency (Cronbach's α: 0.887) and test-retest reliability were demonstrated. CONCLUSION: The Spanish version of the WHOQOL-BREF questionnaire is useful and reliable to evaluate the quality of life of persons with spinal cord injuries in our population of Spanish-speaking people.

Risks factors of mechanical ventilation in acute traumatic cervical spinal cord injured patients.

STUDY DESIGN: Descriptive retrospective study. OBJECTIVES: To analyze risk factors associated with mechanical ventilation (MV) in cases of acute traumatic Cervical Spinal Cord Injury (tCSCI). SETTING: Unidad de Lesionados Medulares, Complejo Hospitalario Universitario A Coruña, in Galicia (Spain). METHODS: The study included patients with tCSCI who were hospitalized between January 2010 and December 2014. The following variables were analyzed: age, gender, etiology, neurological level, ASIA (American Spinal Injury Association) grade, associated injuries, injury severity score (ISS), ASIA motor score (AMS) at admission and mortality. RESULTS: A total of 146 patients met the study's inclusion criteria. The majority were men (74.7%) with mean age of 62.6 (s.d. ± 18.8) years. Sixty patients (41.1%) required MV. Mean age of ventilated vs. non-ventilated patients was 57.3 vs. 65.7. Men were more likely to require MV than women, ASIA grades A and B were also more likely to need MV than grades C and D, as well as patients with associated injuries. The AMS of patients receiving MV was lower than that of those who did not require MV (20.1 vs. 54.3). Moreover, the ISS was higher in patients receiving MV (31.2 vs. 13.4). An AMS ≤ 37 and an ISS ≥ 13 increased the risk of requiring MV by a factor of 11.98 and 7.28, respectively. CONCLUSIONS: Isolated factors associated with a greater risk of MV in tCSCI were: age, gender, ASIA grade, ISS and AMS. However, the only factor with a significant discriminatory ability to determine the need for MV was the AMS at admission.

Refractory orthostatic hypotension in a patient with a spinal cord injury: Treatment with droxidopa.

CONTEXT: Orthostatic hypotension (OH) is a common complication in patients with a spinal cord injury, mainly affecting complete injuries above neurological level T6. It is generally more severe during the acute phase but can remain symptomatic for several years. FINDINGS: A 65-year-old male with a grade ASIA A post-traumatic cervical spinal cord injury, at neurological level C4, presenting with symptomatic refractory OH. Increased blood pressure (BP) levels and an overall clinical improvement was observed after administering an increasing dose of droxidopa. Treatment was started at a dose of 100 mg twice daily (bid), one to be taken upon rising in the morning and another one in the afternoon, at least three hours before bedtime. According to the patient's symptomatic response, each individual dose was increased by 100 mg at 48-hour intervals. Both increased mean BP levels and a subjective symptomatic improvement were evidenced at a dose of 300 mg bid. CLINICAL RELEVANCE: Treatment with droxidopa increases BP levels and improves symptoms related to refractory OH using all physical and pharmacological measures available. It could therefore constitute an effective alternative treatment for OH in patients with a spinal cord injury.

Respiratory management in the patient with spinal cord injury.

Spinal cord injuries (SCIs) often lead to impairment of the respiratory system and, consequently, restrictive respiratory changes. Paresis or paralysis of the respiratory muscles can lead to respiratory insufficiency, which is dependent on the level and completeness of the injury. Respiratory complications include hypoventilation, a reduction in surfactant production, mucus plugging, atelectasis, and pneumonia. Vital capacity (VC) is an indicator of overall pulmonary function; patients with severely impaired VC may require assisted ventilation. It is best to proceed with intubation under controlled circumstances rather than waiting until the condition becomes an emergency. Mechanical ventilation can adversely affect the structure and function of the diaphragm. Early tracheostomy following short orotracheal intubation is probably beneficial in selected patients. Weaning should start as soon as possible, and the best modality is progressive ventilator-free breathing (PVFB). Appropriate candidates can sometimes be freed from mechanical ventilation by electrical stimulation. Respiratory muscle training regimens may improve patients' inspiratory function following a SCI.